Marsha fights every day her personal battle against Thalassemia Major, a type of anemia that requires a continuous transfusions. Marsha is 43 years old and until now she has received a thousand blood bags. Marsha is an Italian-American woman, a native of Calabria. She perform as a comedienne, founding “The Rome Comedy Club” the first english cabaret in Rome. Every fifteen days in her life, a phone call arrives on time, a code, few words than the transfusion to survive. Thalassemia Major: an hereditary disease caused by a gene mutation, the more widespread disease in the world, located in the Mediterranean basin and in Southeast Asia and affects about 8,5% of the world population. Thalassemia Major is the most severe form of beta thalassemia in which the complete lack of beta protein in the hemoglobin causes life-threatening anemia, that requires regular blood transfusions and frequent checks. Blood transfusions for life lead to iron